Polyacelylenic alcohols and alkaloid derivatives from a calcareous marine sponge, Leucetta chagosensis

A chemical investigation of the CH2Cl2 extract of the marine sponge Leucetta chagosensis afforded 8 secondary metabolites, namely, pellynol A (1), pellynol B (2), pellynol I (3), pellynol D (4), plakohypaphorine B (5), plakohypaphorine E (6), 4-bromo-1H-pyrrole-3-carboxamide (7), and 2-phenylacetamide (8). The structures of these secondary metabolites were elucidated via NMR spectroscopic analysis, MS experiment and compared with those reported in the literature. This is the first report of compounds 1-8 isolated from the marine sponge genus Leucetta and from the class Calcarea. This work contributes expands the knowledge of the chemical diversity of calcareous marine sponges, and the chemotaxonomic significance of the isolates is also discussed.