Identification of immune subtypes and prognosis of hepatocellular carcinoma based on immune checkpoint gene expression profile.

•TCGA and GEO data were used to analyze 47 immune checkpoint genes (ICGs) finding that there is a certain synergy between ICGs.•Survival analysis of TCGA dataset yields a set of ICGs that have a significant relationship with prognosis•Combining tumor mutation burden and neoantigen, we found that the expression of the gene NRP1 was significantly negatively correlated with TMB and neoantigens.