Musk ketone induces neural stem cell proliferation and differentiation in cerebral ischemia via activation of the PI3K/Akt signaling pathway.

Zheyi Zhou,Linglu Dun,Bingxin Wei,Yanyan Gan,Zhongling Liao,Xiumiao Lin,Junlei Lu,Guocheng Liu,Hong Xu,Changjun Lu,Hongwei An

Neuroscience（2020）

引用 55|浏览16

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摘要

•The role of musk ketone in cerebral ischemia is investigated.•NSC proliferation and differentiation reduces cerebral ischemic injury.•Musk ketone promotes NSC proliferation and differentiation.•Musk ketone is neuroprotective in cerebral ischemia injury via PI3K/Akt activation.•This study provides a novel therapeutic target for the treatment of cerebral ischemia.

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ECA,HEPES,MCAO,NSCs,OGD,PBS,TTC

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