Mechanisms of memory impairment induced by orexin-A via orexin 1 and orexin 2 receptors in post-traumatic stress disorder rats.

Dan Han, Fang Han,Yuxiu Shi,Shilei Zheng,Lili Wen

Neuroscience（2020）

引用 17|浏览11

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摘要

•SPS causes spatial memory deficits and dysregulation of appetite.•SPS induces upregulation of OX1R and OX2R in the hippocampus and of OX1R in the hypothalamus.•Changes in behavior and OX1R/OX2R expression induced by SPS were partly reversed by orexin-A administration.

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关键词

ANOVA,cAMP,CSF,DG,DMH,GPCRs,HPA,i.c.v.,LH,mRNA,MWM,OD,OX1R,OX2R,PCR,PeF,PFA,PH,PNT,PTSD,SABC,SPS,SPT

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