Novel benzoate-lipophilic cations selectively induce cell death in human colorectal cancer cell lines.

José Antonio Jara,Diego Rojas,Vicente Castro-Castillo,Sebastián Fuentes-Retamal,Cristian Sandoval-Acuña,Eduardo Parra,Mario Pavani,Juan Diego Maya,Jorge Ferreira,Mabel Catalán

Toxicology in Vitro（2020）

引用 8|浏览22

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摘要

•Benzoic acid esters attached to the triphenylphosphonium group.•Evaluating the cytotoxicity and modes of action in colorectal cancer cells.•The new compounds were able to exert an uncoupling effect in colorectal cancer cells.•Benzoate-TPP+ derivatives are capable of inducing apoptosis.

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关键词

Targeting mitochondria,Benzoic acid derivatives,Uncoupling agents,Metabolism stress,Triphenylphosphonium moiety,Colorectal cancer,Antitumour-mitochondrial agents

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