Distinct tribological endotypes of pathological human synovial fluid reveal characteristic biomarkers and variation in efficacy of viscosupplementation at reducing local strains in articular cartilage.

Rebecca M Irwin,Elizabeth Feeney, Cynthia Secchieri,Devis Galesso,Itai Cohen,Francesca Oliviero,Roberta Ramonda,Lawrence J Bonassar

Osteoarthritis and Cartilage（2020）

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摘要

These results suggest that pathological SF is characterized by distinct tribological endotypes where SF lubricating behaviors are differentially modified by viscosupplementation and are identifiable by biomarkers.

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关键词

Arthritis,Osteoarthritis,Friction,Hyaluronic acid,Lubricin,Inflammation

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