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Imipridone Anticancer Compounds Ectopically Activate the ClpP Protease and Represent a New Scaffold for Antibiotic Development

Samuel Jacques,Almer M. van der Sloot,Caroline Huard,Jasmin Coulombe-Huntington,Sarah Tsao,Sylvain Tollis,Thierry Bertomeu,Elizabeth J. Culp,Daniel Pallant,Michael A. Cook,Eric Bonneil,Pierre Thibault,Gerard D. Wright,Mike Tyers

Genetics（2020）

引用 42|浏览65
关键词
AAA plus ATPase,antibiotic,CLPP,CRISPR screen,imipridone,MIPEP,mitochondrion,proteolysis,proteome,synergism
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