Analysis of Whole CDR3 TCR Repertoire after Hematopoietic Stem Cell Transplantation in Two Clinical Cohorts.

O Shah, J S Tamaresis, L J Kenyon, L Xu,P Zheng, P Gupta, K RangarajanK,S Lee,S Spellman,S Nikiforow,J Zehnder,E H Meyer

Biology of Blood and Marrow Transplantation（2020）

Cited 5|Views17

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Abstract

•Using MCA and a data reduction model, we were able to show that not only were clones shared across patient samples, but also there are specific TRBV families that were seen predominantly in those who responded to steroids.•We found a statistically significant decreasing trend in diversity measures over time.•We offer an honest discussion that better reflects the current literature and our study limitations and its merits.

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Key words

T-cell receptor,T cell,Graft-versus-host disease,CDR3,Stem cell transplantation

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