TMEM16A Ca 2+ -activated Cl - channel inhibition ameliorates acute pancreatitis via the IP 3 R/Ca 2+ /NFκB/IL-6 signaling pathway.

Qinghua Wang,Lichuan Bai,Shuya Luo,Tianyu Wang,Fan Yang, Jialin Xia,Hui Wang,Ke Ma, Mei Liu,Shuwei Wu,Huijie Wang,Shibin Guo,Xiaohong Sun,Qinghuan Xiao

Journal of Advanced Research（2020）

引用 35|浏览40

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摘要

A positive activation loop between TMEM16A and the IP3R/Ca2+/NFκB/IL-6 pathway is important for Ca2+ elevation, NFκB activation and IL-6 release, and thus cooperatively promotes the pathogenesis of AP.

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关键词

TMEM16A,Inositol 1,4,5-trisphosphate receptor,Acute pancreatitis,NFκB,Interleukin-6

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