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Dexmedetomidine protects H9C2 against hypoxia/reoxygenation injury through miR-208b-3p/Med13/Wnt signaling pathway axis.

Zhuoran Wang,Yuqiao Yang,Wei Xiong,Rui Zhou,Ning Song,Lan Liu,Jinqiao Qian

Biomedicine & Pharmacotherapy（2020）

Cited 22|Views4
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Abstract
•miR-208b-3p is upregulated in H9C2 undergoing Hypoxia/reoxygenation.•Dexmedetomidine reduces upregulation of miR-208b-3p caused by Hypoxia/reoxygenation in H9C2.•Med13 is a direct target gene of miR-208b-3p.•Dexmedetomidine induces protective effect on H9C2 via miR-208b-3p/Med13/Wnt/β-catenin signaling pathway axis.
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AMI,CABG,Dex,DMEM,ECL,FBS,HR,I/R,miRNAs,MI,PCI,PMSF,PVDF,qRT-PCR,UTR
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