Blockade of Nogo-A/NgR1 inhibits autophagic activation and prevents secondary neuronal damage in the thalamus after focal cerebral infarction in hypertensive rats.
Neuroscience（2020）
Abstract
•Overexpression of Nogo-A/NgR1 coincided with autophagic activation in the ipsilateral thalamus after cerebral infarction.•Blockade of Nogo-A/NgR1 markedly reduced autophagic activation and secondary thalamic damage after cerebral infarction.•Deactivation of Nogo-A signaling accelerated somatosensory function recovery after cerebral infarction.
MoreTranslated text
Key words
MCAO,NgR,RHRSP,ROCK1,SD,SQSTM1
AI Read Science
Must-Reading Tree
Example
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined