PlexinA3 interacts with CRMP2 to mediate Sema3A signalling during dendritic growth in cultured cerebellar granule neurons.

Tao Jiang,Guowei Zhang,Yaozhong Liang,Zhenbin Cai,Zhi Liang,Hongsheng Lin,Minghui Tan

Neuroscience（2020）

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摘要

•PlexinA3 colocalizes and interacts with CRMP2 via RBD region in dendrites of CGNs.•PlexinA3 is necessary and sufficient for dendritic growth of CGNs.•CRMP2 functions as downstream of PlexinA3.•PlexinA3/CRMP2 signalling is responsible for Seme3A-mediated dendritic growth.

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关键词

CGN,CRMP2,DIV,EDTA,EGTA,GST,RBD,siRNA

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