Synthesis of sulpha drug based hydroxytriazene derivatives: Anti-diabetic, antioxidant, anti-inflammatory activity and their molecular docking studies.

Bioorganic Chemistry(2020)

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摘要
•Synthesis of novel hydroxytriazenes incorporating sulphanilamide, sulphadiazine, sulphapyridine and sulphaguanidine moiety.•Predication of probable biological activities through PASS online web tool.•Evaluation of antidiabetic activity by α-glucosidase and α-amylase inhibition method, antioxidant activity by DPPH and ABTS radical scavenging method and anti-inflammatory activity by carrageenan induced paw edema method.•Docking study for antidiabetic activity to know mechanism of action.
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关键词
Hydroxytriazenes,Sulpha drugs,Antioxidant,Anti-diabetic,Anti-inflammatory activity
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