Synthesis of sulpha drug based hydroxytriazene derivatives: Anti-diabetic, antioxidant, anti-inflammatory activity and their molecular docking studies.
Bioorganic Chemistry(2020)
摘要
•Synthesis of novel hydroxytriazenes incorporating sulphanilamide, sulphadiazine, sulphapyridine and sulphaguanidine moiety.•Predication of probable biological activities through PASS online web tool.•Evaluation of antidiabetic activity by α-glucosidase and α-amylase inhibition method, antioxidant activity by DPPH and ABTS radical scavenging method and anti-inflammatory activity by carrageenan induced paw edema method.•Docking study for antidiabetic activity to know mechanism of action.
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关键词
Hydroxytriazenes,Sulpha drugs,Antioxidant,Anti-diabetic,Anti-inflammatory activity
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