Molecular hydrogen attenuates sepsis-induced neuroinflammation through regulation of microglia polarization through an mTOR-autophagy-dependent pathway

•Molecular hydrogen protects against sepsis-induced cognitive impairment in mice.•Molecular hydrogen ameliorates sepsis-induced neuroinflammation in mice and BV-2 cells.•Molecular hydrogen regulates sepsis-induced microglia polarization via mTOR-autophagy pathway.