Determination of the glomerular filtration rate in patients with type 2 diabetes: an assessment of the agreement between 51 Cr-EDTA plasma clearance and 99m Tc-DTPA plasma clearance, 99m Tc-DTPA renography and plasma creatinine prediction equation.

Diabetes Research and Clinical Practice(2020)

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Abstract
•Lack of robust evidence on 51Cr-EDTA and 99mTc-DTPA plasma clearance agreement.•Renographic Gates’ method and serum creatinine equations are used for GFR measurement.•In comparative studies patients with diabetes are under-represented or missing.•A close agreement is shown between 51Cr-EDTA and 99mTc-DTPA plasma clearance.•99mTc-DTPA plasma clearance can replace 51Cr-EDTA in patients with type 2 diabetes.•Renographic Gates’ method and the CKD-EPI equation cannot assess GFR reliably.
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Key words
51Cr-EDTA,CKD-EPI,Diabetic nephropathy,Gates’ method,Glomerular filtration rate,99mTc-DTPA
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