Resveratrol prevented experimental pulmonary vascular remodeling via miR-638 regulating NR4A3/cyclin D1 pathway.
Microvascular Research（2020）
Abstract
•MCT induced miR-638 down-regulation and NR4A3 up-regulation.•Resveratrol prevented MCT-induced pulmonary vascular remodeling.•Resveratrol suppressed PASMCs proliferation via miR-638 up-regulation.•NR4A3 is a direct target of miR-638 in PASMCs proliferation.
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Key words
Pulmonary vascular remodeling,miR-638,NR4A3,Cyclin D1,Resveratrol
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