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Suppressed dendritic cell functions by cystatin C lead to compromised immunity in vivo.

Shun Chen,Lei Liu,Wenjie Zhang,Li Sun,Fengge Wang,Yanfang Zhao,Shan Liu, Lin Zhao,Yuekang Xu

Cellular Immunology（2020）

Cited 3|Views14
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Abstract
•CstC alleviates DC-induced T cell proliferation partly independent of cell-contact.•CstC-transduced DCs suppress CD8+ T cell immunity and compromise tumor rejection.•CstC-transduced DCs enhance Treg/Th17 ratio and relieve autoimmune arthritis.
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Key words
Cystatin C,Dendritic cells,T cell proliferation,T cell differentiation,Autoimmunity
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