Transcriptional Correlates of Tolerance and Lethality in Mice Predict Ebola Virus Disease Patient OutcomesWOS
Cell reports, pp. 17022020.
Keywords:Collaborative CrossEbolaclassificationhost responsepathogenesisview more (3+)
Host response to infection is a major determinant of disease severity in Ebola virus disease (EVD), but gene expression programs associated with outcome are poorly characterized. Collaborative Cross (CC) mice develop strain-dependent EVD phenotypes of differential severity, ranging from tolerance to lethality. We screen 10 CC lines and id...More