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Biosynthetic Gene Cluster Identification And Biological Activity Of Lucilactaene From Fusarium Sp. Rk97-94

Sho Kato,Takayuki Motoyama,Yushi Futamura,Masakazu Uramoto,Toshihiko Nogawa,Toshiaki Hayashi,Hiroshi Hirota,Akira Tanaka,Naoko Takahashi-Ando,Takashi Kamakura,Hiroyuki Osada

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY（2020）

Cited 13|Views29
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Abstract
We identified the biosynthetic gene cluster for lucilactaene, a cell cycle inhibitor from a filamentous fungus Fusarium sp. RK 97-94. The luc1 knockout strain accumulated demethylated analogs, indicating the involvement of Luc1 methyltransferase in lucilactaene biosynthesis. Lucilactaene showed potent antimalarial activity. Our data suggested that methylation and ether ring formation are essential for its potent antimalarial activity.
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Key words
Natural products, biosynthesis, PKS-NRPS, biological activity, malaria
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