Hydroethanolic extract from Endopleura uchi (Huber) Cuatrecasas and its marker bergenin: Toxicological and pharmacokinetic studies in silico and in vivo on zebrafish.

Beatriz Martins de Sá Hyacienth,Karyny Roberta Tavares Picanço,Brenda Lorena Sánchez-Ortiz,Luciane Barros Silva,Arlindo César Matias Pereira,Larissa Daniele Machado Góes,Raphaelle Sousa Borges, Rodrigo Cardoso Ataíde,Cleydson Breno Rodrigues Dos Santos,Helison de Oliveira Carvalho, Gloria Melisa Gonzalez Anduaga,Andrés Navarrete,José Carlos Tavares Carvalho

Toxicology Reports（2020）

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摘要

•E. uchi stem bark hydroethanolic extract in zebrafish.•Evaluating the in silico pharmacokinetic and toxicological parameters.•Behavioral, biochemical and histopathological changes was dose dependent.•In silico bergenin and its metabolites showed high intestinal absorption.•Bergenin inhibited CYP2C9, CYP3A4 and CYP2C19.

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ALT,AST,BBB,EEu,HBA,HBD,hERG,HIA,IAN,HAI,MM,P-Gp,PPB

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