Cadmium induces mitochondrial ROS inactivation of XIAP pathway leading to apoptosis in neuronal cells.

Rui Zhao,Qianyun Yu,Long Hou,Xiaoqing Dong,Hai Zhang,Xiaoling Chen,Zhihan Zhou,Jing Ma,Shile Huang,Long Chen

The International Journal of Biochemistry & Cell Biology（2020）

引用 26|浏览18

暂无评分

摘要

•Cd induces mitochondrial ROS, causing inactivation of XIAP-MDM2-p53 pathway in neuronal cells.•ROS-inactivated XIAP-MDM2-p53 pathway plays a critical role in Cd-induced apoptosis.•Modulation of XIAP-MDM2-p53 pathway is a promising approach against Cd-induced neurotoxicity.

查看译文

关键词

AD,Cd,CM-H2DCFDA,CNS,DAPI,DMEM,FBS,GSH,HD,IOD,MDM2,NAC,PBS,PD,PDL,ROS,Ser/Thr,TOM20,TUNEL,XIAP

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要