Full genome based sequence and structural characterization of an unusual group A rotavirus G12P[11] isolated from neonates in Pune, western India.

Vaccine(2020)

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摘要
•NIV-1740121 G12P[11] exhibited Wa-like genotype constellation.•The strain might have undergone multiple-gene reassortment events.•Localized charge changes in VP7 may affect interaction with neutralizing antibodies.•Type I glycan binds G12P[11] VP8* in similar pattern at the same active site as N155.
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关键词
Rotavirus,Neonates,Reassortant,G12P[11] strains,Genome,Age-restricted tropism
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