Structural Optimization of the Diarylurea PSNCBAM-1, an Allosteric Modulator of Cannabinoid Receptor 1.

Rachel Dopart,Sri Sujana Immadi,Dai Lu,Debra A Kendall

Current Therapeutic Research（2020）

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摘要

•PSNCBAM-1 is an allosteric modulator of the cannabinoid receptor 1.•Derivatives of PSNCBAM-1 were made, to reduce the total rings in the structure.•Several derivatives maintained allosteric activity, as shown by binding experiments.•Some calculated physicochemical properties for these derivatives are provided.

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关键词

allosteric modulator,cannabinoid,CB1 receptor,diarylurea

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