YAP-depleted iPSC MUSIi012-A-2 maintained all normal stem cell characteristics.

Chanchao Lorthongpanich,Chuti Laowtammathron,Nittaya Jiamvoraphong,Pimonwan Srisook,Pimjai Chingsuwanrote,Phatchanat Klaihmon,Nattaya Damkham,Papussorn Terbto,Supaporn Waeteekul,Yaowalak U-Pratya,Surapol Issaragrisil

Stem cell research（2020）

引用 4|浏览19

暂无评分

摘要

Yes-associated protein (YAP) is an important transcriptional coactivator in the Hippo signaling pathway. Using CRISPR/Cas9 technology, we established a stable YAP-knockdown (YAP-KD) induced pluripotent stem cell (iPSC) from the MUSIi012-A cell line. The YAP-KD iPSC MUSIi012-A-2 maintained the pluripotent phenotype, the ability to differentiate into all three embryonic germ layers, and it maintained the normal karyotype.

查看译文

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要