Neurological safety of oxaliplatin in patients with uncommon variants in Charcot-Marie-tooth disease genes.

Jennifer G Le-Rademacher,Camden L Lopez,Rahul Kanwar,Brittny Major-Elechi,Alexej Abyzov,Michaela S Banck,Terry M Therneau,Jeff A Sloan,Charles L Loprinzi,Andreas S Beutler

Journal of the Neurological Sciences（2020）

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摘要

Oxaliplatin therapy can be complicated by chemotherapy-induced peripheral neuropathy (CIPN). Other neurotoxic chemotherapies have been linked to single nucleotide variants (SNV) in Charcot-Marie-Tooth disease (CMT) genes. Whether oxaliplatin carries increased risks of CIPN due to SNV in CMT-associated genes is unknown.

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关键词

Oxaliplatin,Neuropathy,Hereditary,Risk factors,Charcot-Marie-tooth disease,Chemotherapy

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