Comparison of MIC Test Strip and Sensititre YeastOne with the broth microdilution reference methods CLSI and EUCAST for in vitro antifungal susceptibility testing of Cryptococcus neoformans .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY(2020)
摘要
We compared MIC test strip (MTS) and Sensititre YeastOne (SYO) methods with EUCAST and CLSI methods for amphotericin B, 5-fluocytosine, fluconazole, voriconazole, and isavuconazole against 106 Cryptococcus neoformans isolates. The overall essential agreement between the EUCAST and CLSI methods was >72% and >94% at +/- 1 and +/- 2 dilutions, respectively. The essential agreements between SYO and EUCAST/CLSI for amphotericin B, 5-flucytosine, fluconazole, and voriconazole were >89/>93% and between MTS and EUCAST/CLSI were >57/>75%. Very major error rates were low for amphotericin B and fluconazole (<3%) and a bit higher for the other drugs (<8%).
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关键词
CLSI,Cryptococcus neoformans,EUCAST,Liofilchem MIC test strip,Sensititre YeastOne,antifungal susceptibility
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