Spinal caspase-6 contributes to remifentanil-induced hyperalgesia via regulating CCL21/CXCR3 pathway in rats.
Neuroscience Letters（2020）
Abstract
•Remifentanil induces mechanical allodynia and thermal hyperalgesia.•Remifentanil increases spinal caspase-6 secretion and CCL21/CXCR3 expression.•Central caspase-6 inhibition reduces hyperalgesia and spinal expression of CCL21/CXCR3.•Pharmacologic blockage of CCL21/CXCR3 alleviates hyperalgesia.•Central CCL21 inhibition reverses the caspase-6 evoked allodynia.
MoreTranslated text
Key words
Caspase-6,CCL21,CXCR3,Remifentanil-induced hyperalgesia,Spinal cord
AI Read Science
Must-Reading Tree
Example
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined