An organocatalytic asymmetric Friedel-Crafts reaction of 2-substituted indoles with aldehydes: enantioselective synthesis of -hydroxyl ketones by low loading of chiral phosphoric acid
CHEMICAL COMMUNICATIONS(2020)
摘要
Hydroxyl alkylation of indoles by Friedel-Crafts reaction with a carbonyl compound is a useful strategy. However, the reaction was restricted to ketones due to the easy formation of a bisindole byproduct. Therefore, hydroxyl alkylation of an aldehyde with indole is confronted with great challenges. Here, we report an efficient strategy for asymmetric hydroxyl alkylation of 2-substituted indoles with aldehydes under 0.1 mol% chiral phosphoric acid. A series of alpha-hydroxyl ketones were obtained in high yields (up to 99%) and good enantioselectivities (up to 97%).
更多查看译文
关键词
enantioselective synthesis,organocatalytic asymmetric friedel–crafts,indoles,ketones
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要