White matter structure and myelin-related gene expression alterations with experience in adult rats.

Cassandra Sampaio-Baptista,Astrid Vallès,Alexandre A Khrapitchev, Guus Akkermans,Anderson M Winkler,Sean Foxley,Nicola R Sibson,Mark Roberts,Karla Miller,Mathew E Diamond,Gerard J M Martens,Peter De Weerd,Heidi Johansen-Berg

Progress in Neurobiology（2020）

引用 28|浏览61

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摘要

•Somatosensory experience results in DTI changes in white matter (WM).•Macroscale metrics of WM structure correlate with mRNA markers of cortical activity.•MBP immunohistochemistry and mRNA expression indicate changes in myelin.•Both molecular and cellular evidence are consistent with DTI findings.•Myelination is one component of macroscale measures of WM plasticity.

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关键词

mRNA expression,White matter,MRI,Myelin,Genome-wide RNA sequencing,Plasticity

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