Who is willing to participate in research? A screening model for an anxiety and depression trial in the epilepsy clinic.

•In an epilepsy clinic, 77% agreed to research screening for a mental health study.•Antidepressant therapy was ongoing in 43% at time of + anxiety or depression screen.•Higher depression score was independently associated with research participation.•Antidepressant therapy was independently associated with research participation.•Nearly 50% with + anxiety or depression screen were untreated at time of screen.