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Microbial Diversity and Composition Is Associated with Patient -Reported Toxicity during Chemoradiation Therapy for Cervical Cancer

Aparna Mitra,Greyson Willis Grossman Biegert, Andrea Y. Delgado, Tatiana V. Karpinets,Travis N. Solley,Melissa P. Mezzari, Kyoko Yoshida-Court, Joe F. Petrosino,Megan D. Mikkelson, Lilie Lin,Patricia Eifel,Jianhua Zhang, Lois M. Ramondetta, Anuja Jhingran,Travis T. Sims,Kathleen Schmeler,Pablo Okhuysen, Lauren E. Colbert,Ann H. Klopp

International Journal of Radiation Oncology*Biology*Physics（2020）

Cited 38|Views72
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Abstract
Over time, increased radiation toxicity is associated with decreased gut microbiome diversity. Baseline diversity is not predictive of end-of-treatment bowel toxicity but composition may identify patients at risk for developing high toxicity.
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Key words
Gut microbiome,Radiation,Toxicity
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