Cancer causes metabolic perturbations associated with reduced insulin-stimulated glucose uptake in peripheral tissues and impaired muscle microvascular perfusion.

•Tumor-bearing mice displayed marked insulin resistance (IR) and glucose intolerance.•Cancer impaired skeletal muscle and adipose tissue insulin-stimulated glucose uptake.•Insulin-stimulated muscle microvascular perfusion was abolished in tumor-bearing mice.•Tumor-bearing mice displayed increased basal hepatic glucose production.•Cancer-associated IR was restored by fatty acid oxidation inhibition.