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Human omental adipose-derived mesenchymal stem cells enhance autophagy in ovarian carcinoma cells through the STAT3 signalling pathway

Yijing Chu,Yan Wang,Kun Li,Meixin Liu,Yan Zhang, Yan Li,Xiaoyu Hu,Chong Liu,Huansheng Zhou,Jianxin Zuo,Wei Peng

Cellular Signalling（2020）

Cited 14|Views5
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Abstract
•ADSCs abound in omentum enhanced autophagy in ovarian carcinoma cells with elevated growth and metastasis properties•ADSC-conditioned medium significantly activated STAT3 in ovarian carcinoma cells•l STAT3 inhibition attenuated the ADSC induced increased ovarian carcinoma cells autophagy, growth and invasion•Our data provide a novel insight into the mechanism how the adipose derived stem cells fuels the spread of ovarian carcinoma.
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Key words
Ovarian cancer,Adipose mesenchymal stem cells,Autophagy,STAT3 signalling pathway
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