Aerobic dehydrogenation of amines to nitriles catalyzed by triazolylidene ruthenium complexes with O 2 as terminal oxidant.

DALTON TRANSACTIONS(2020)

Cited 17|Views2
No score
Abstract
Pyridyl-substituted mesoionic triazolylidene ruthenium cymene complexes catalyze the oxidation of both aromatic and aliphatic amines to nitriles with high activity and selectivity under benign conditions using dioxygen as the terminal oxidant. Modification on the pyridyl moiety of the ligand scaffold has negligible effect on the catalytic performance, while substituents on the triazolylidene directly affect the catalytic fitness of the metal center, leading to distinct catalytic profiles. Pre-dissociation of the cymene ligand and formation of a solvento analogue further enhances the catalytic activity towards nitrile formation. Variation of reaction conditions provided valuable mechanistic insights and resulted in a highly efficient protocol for nitrile formation with maximum turnover numbers around 10000. The turnover frequency reaches up to 400 h(-1), providing one of the fastest catalytic systems known to date for this transformation.
More
Translated text
Key words
triazolylidene ruthenium complexes,aerobic dehydrogenation,amines,nitriles
AI Read Science
Must-Reading Tree
Example
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined