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Design and production of dengue virus chimeric proteins useful for developing tetravalent vaccines.

Izabella Cristina Andrade Batista,Bárbara Resende Quinan,Érica Alessandra Rocha Alves,Soraya Torres Gaze Jangola,Eneida Santos Oliveira,Stella Garcia Colombarolli,Jorge Gomes Goulart Ferreira,Eliseu Soares de Oliveira Rocha,Erna Geessien Kroon,Rafael Ramiro de Assis,Jaquelline Germano de Oliveira,Jacqueline Araújo Fiuza,Carlos Eduardo Calzavara-Silva

Vaccine（2020）

Cited 2|Views7
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Abstract
Dengue virus (DENV) is a Flavivirus estimated to cause 390 million infections/year. Currently, there is no anti-viral specific treatment for dengue, and efficient DENV vector control is still unfeasible. Here, we designed and produced chimeric proteins containing potential immunogenic epitopes from the four DENV serotypes in an attempt to further compose safer, balanced tetravalent dengue vaccines.
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Key words
Dengue,Tetravalent vaccine,Chimeric proteins
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