HPV induction of APOBEC3 enzymes mediate overall survival and response to cisplatin in head and neck cancer.

Kayla L Conner,Asra N Shaik,Elmira Ekinci,Seongho Kim,Julie J Ruterbusch,Michele L Cote,Steve M Patrick

DNA Repair（2020）

引用 7|浏览13

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摘要

•HPV induces APOBEC3 expression in HNSC.•High APOBEC3 G expression correlates with better overall survival.•APOBEC3, Polβ and MSH6 knockdown results in cisplatin resistance.•Cisplatin resistance following A3 knockdown correlates with ICL repair.

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关键词

HPV,HNSC,A3,BER,MMR,ICLs,UNG,TCGA,OS,IFN,Polβ,MSH6

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