Characterization of Arsenic-Induced Cancer Stem-Like Cells.

Qingshan Chang,Zhuoyue Bi, Yao Fu, M' Kya Anique Rice,Qian Zhang,Priya Wadgaonkar,Bandar Almutairy, Wenxian Zhang,Yongju Lu,Liping Xu, Chitra Thukar, Fei Chen

STEM CELL TRANSCRIPTIONAL NETWORKS: METHODS AND PROTOCOLS, 2ND EDITION(2020)

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摘要
Arsenic is a well-known human carcinogen. However, the mechanisms underlying arsenic-induced carcinogenesis remain elusive. Here we show that chronic and low level of arsenic stress induces transformation of the human bronchial epithelial cells, BEAS-2B, and that some of the transformed cells show characteristics of cancer stem-like cells (CSCs). Meanwhile, we demonstrate that arsenic stress dedifferentiates CD61 BEAS-2B cells into CSC-like CD61 cells featured with noncanonical epithelial-mesenchymal transition (EMT), enhanced chemoresistance, and metastasis. Finally, we show that oncogene c-Myc expression is associated with arsenic-induced tumor initiation and progression. Altogether, our findings highlight a unique mechanism of arsenic-induced transformation of human bronchial epithelial cells and provide a novel therapeutic target for arsenic-initiated lung cancer.
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关键词
Arsenic,Cancer,Cancer stem cells,Environment,Transformation
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