Role of HIF-1α in Cold Ischemia Injury of Rat Donor Heart Via the miR-21/PDCD4 Pathway.

Liang Zhu,Jingzhou Mu,Yunhong Wu,Shanshan Feng,Chang Qu,Tingting Cao,Tangtang Jing,Yan Xie, Lianpu Wen, Zida Fan,Jie Jia,Tonghui Ma

Transplantation Proceedings（2020）

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摘要

•Heart transplantation is a well-established therapy for patients with end-stage heart disease•The injury of cold storage cardiac ultrastructure was significantly aggravated after the 12th hour•Hypoxia-inducible factor 1 alpha and microRNA-21 as multifunctional and downstream factors may play a protective role in heart cold storage

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cold ischemia injury,rat donor heart via

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