Vagal sensory neurons drive mucous cell metaplasia.

Sébastien Talbot,Benjamin Doyle,Junwei Huang,Jo-Chiao Wang,Maryam Ahmadi,David P Roberson,Ajay Yekkirala,Simmie L Foster,Liam E Browne,Bruce P Bean,Bruce D Levy,Clifford J Woolf

The Journal of allergy and clinical immunology（2020）

引用 17|浏览25

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摘要

Airway sensory neuron-produced Substance P heightens allergy-induced goblet cell hyperplasia and hypersecretion of Muc5AC, electrically silencing these overreactive neurons reduced these components of lung type 2 allergic inflammatory response.

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