Afp-Negative Mixed Hepatoid Adenocarcinoma Of The Colon: A Case Report With Review Of Literature

Aim: To investigate the clinicopathologic profile of hepatoid adenocarcinoma (HAC) of the colon and to improve the diagnostic and treatment level. Materials and methods: The clinical observations and histopathologic and immunohistochemical features of HAC were analyzed. Results: HAC is usually composed of well-differentiated common adenocarcinoma and hepatoid differentiation. The tumor cells in hepatoid differentiation area are arranged in trabecular or solid shape, with large polygonal tumor cells, and abundant cytoplasm. Immunohistochemical markers showed the HAC cells were positive for Glypican-3, HepPar1, CK19, and carcinoembryonic antigen (CEA), while alpha-fetoprotein (AFP) was negative. Conclusion: HAC is a rare malignant tumor of the colon. Its diagnosis depends on histopathology and immunohistochemical staining. Surgical resection should be the treatment of choice if possible.