Prevention of peridural adhesions in spinal surgery: Assessing safety and efficacy of Chitogel with Deferiprone in a sheep model.

Rajan Sundaresan Vediappan,Annika Mascarenhas, Ann Nguyen-Hoang,Stephanie Anne Fong,Alistair Jukes,Katharina Richter,Ahmed Bassiouni,Sandy Patel,Steve Chryssidis,Sophia Otto,Stephen Moratti,Alkis James Psaltis,Sarah Vreugde,Peter-John Wormald

Journal of Clinical Neuroscience（2020）

引用 5|浏览16

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摘要

•40% of post-laminectomy patients suffer from Failed Back Surgery syndrome.•Barrier – hydrogels are best bet to prevent adhesion formation post-laminectomy.•Chitogel complexed with the iron chelator Deferiprone is a promising barrier.•Chitogel prevents inflammation and adhesion as seen in a sheep laminectomy model.

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关键词

Back pain,Epidural adhesion,Fibrosis,Chitogel,Failed Back surgery syndrome

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