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Inhibition of LOX-1 prevents inflammation and photoreceptor cell death in retinal degeneration.

Xinran Gao,Ruilin Zhu,Jiantong Du,Wenbo Zhang,Wenna Gao,Liu Yang

International Immunopharmacology（2020）

Cited 4|Views7
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Abstract
•Expression of LOX-1 are elevated in retinal degeneration.•Inhibition of LOX-1 reduces pro-inflammatory cytokines in retinal degeneration.•Inhibition of LOX-1 prevents photoreceptor cell death in retinal degeneration.•Inhibition of LOX-1 reduces microglial neurotoxicity on photoreceptors.
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Key words
LOX-1,Inflammation,Photoreceptor cell death,Retinal degeneration,Light damage
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