miR-7112-3p targets PERK to regulate the endoplasmic reticulum stress pathway and apoptosis induced by photodynamic therapy in colorectal cancer CX-1 cells.
Photodiagnosis and Photodynamic Therapy（2020）
Abstract
•MiR-7112-3p is highly expressed in colorectal cancer tissue, which directly targets PERK in CX-1 cells.•Endoplasmic reticulum is involved in the subcellular accumulation of DVDMS in CX-1 cells.•Depressed expression of miR-7112-3p alleviated the inhibition of PERK and induced apoptosis by DVDMS-PDT.
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Key words
Colorectal cancer,miR-7112-3p,Photodynamic therapy,Endoplasmic reticulum stress,PERK,Apoptosis
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