Dosimetric Feasibility Of Utilizing The Viewray Magnetic Resonance Guided Linac System For Image-Guided Spine Stereotactic Body Radiation Therapy
CUREUS(2019)
Abstract
Introduction: Spine stereotactic body radiation therapy (SBRT) achieves favorable outcomes compared to conventional radiotherapy doses/fractionation. The spinal cord is the principal dose-limiting organ-at-risk (OAR), and safe treatment requires precise immobilization/localization. Therefore, image guidance is paramount to successful spine SBRT. Conventional X-ray imaging and alignment to surrogate bony anatomy may be inadequate, whereas magnetic resonance imaging (MRI) directly visualizes the dose-limiting cord. This work assessed the dosimetric capability of the ViewRay (ViewRay Inc. Oakwood Village, OH) magnetic resonance (MR) guided linac (MR-Linac) for spine SBRT.Methods: Eight spine SBRT patients without orthopedic hardware who were previously treated on a TrueBeam using volumetric modulated arc therapy (VMAT) were re-planned using MR-Linac fixed-field intensity-modulated radiation therapy (IMRT). Phantom measurements using film, ionization chamber, and a commercial diode-array assessed feasibility. Plans included a variety of prescriptions (30-50 Gy in 3-10 fractions).Results: MR-Linac plans satisfied all clinical goals. Compared to VMAT plans, both entrance dose and heterogeneity increased (D-max: 134 +/- 3% vs. 120 +/- 2%, p=0.0270), while conformality decreased (conformity index: 1.28 +/- 0.06 vs. 1.06 +/- 0.06, p=0.0005), and heterogeneity increased. However, while not statistically significant, MR-linac cord sparing improved (cord D-max: 16.1 +/- 2.7Gy vs. 19.5 +/- 1.6Gy, p=0.2066; cord planning organ at risk volume (cord PRV) D-max: 20.0 +/- 2.6Gy vs. 24.5 +/- 2.0Gy, p=0.0996). Delivery time increased but was acceptable (14.39 +/- 1.26min vs. 9.57 +/- 1.19min). Ionization chamber measurements agreed with planned dose to within 2.5%. Film and diode measurements demonstrated accurate/precise delivery of dose gradients between the target and the cord.Conclusion: Spine SBRT with the MR-Linac is feasible as verified via re-planning eight clinical cases followed by delivery verification in phantoms using film, diodes, and an ionization chamber. Real-time visualization of the dose-limiting cord during spine SBRT may enable cord-based gating, reduced margins, alternate dose schemas, and/or adaptive therapy.
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Key words
spine sbrt, igrt, mr-igrt, magnetic resonance-guided radiation therapy (mrgrt), dosimetry treatment planning
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