High Expression Of Hax-1 Protein Is Associated With Tumor Growth In Papillary Thyroid Carcinoma
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY(2018)
Abstract
Papillary thyroid carcinoma (PTC) is the most common type of endocrine malignancy. HS1-associated protein X-1 (HAX-1) is an anti-apoptotic factor involved in the development of many types of cancer. However, its functional role in human PTC remains unclear. Here we investigated HAX-1 overexpression in human PTC samples and correlated with tumor size and TNM stage. Decreased expression of HAX-1 significantly inhibited proliferation, migration, and invasion in papillary thyroid cancer cell lines TPC1 and K1. Furthermore, we found that down-regulation of HAX-1 induced cell apoptosis. Our results suggest that HAX-1 plays a significant role in regulating the biological behavior in PTC cells and may contribute to PTC target therapy.
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Key words
HAX-1, papillary thyroid carcinoma, apoptosis, migration, invasion
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