Peptide-based short single -strand mimics without hydrogen bonding or aggregation

Generation of short peptides with a single beta-strand structure in solution is difficult. Herein, we design a new class of single beta-strand peptidic mimics that are stable without self-aggregation in protic and non-protic solvents. Introduction of one present beta-strand mimic can induce and propagate the beta-strand structure for at least a penta-peptide sequence.