Molecular characterization of a MOSPD2 homolog in the barbel steed (Hemibarbus labeo) and its involvement in monocyte/macrophage and neutrophil migration.
Molecular Immunology（2020）
Abstract
•We characterized the expression and function of mospd2 in the barbel steed.•Mospd2 gene expression was altered in response to lipopolysaccharide treatment or Aeromonas hydrophila infection.•MOSPD2 protein is located on MO/MФ, neutrophil, and lymphocyte membranes.•MOSPD2 blockade significantly reduced monocytes/macrophages and neutrophils migration.
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Key words
Barbel steed,MOSPD2,Monocyte/macrophage,Neutrophil,Migration
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