Orexin-A exacerbates Alzheimer's disease by inducing mitochondrial impairment.

Maoyu Li, Yao Meng,Bingcong Chu,Yang Shen,Xinhong Xue,Chaoyuan Song,Xiangtian Liu,Mao Ding,Xi Cao,Ping Wang,Shunliang Xu,Jianzhong Bi,Zhaohong Xie

Neuroscience Letters（2020）

Cited 14|Views7

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Abstract

•Orexin-A aggravated cognitive deficit in APP/PS1 mice.•Orexin-A promoted Aβ accumulation in APP/PS1 mice.•Orexin-A aggravated mitochondrial impairment in APP/PS1 mice.•Orexin-A aggravated mitochondrial impairment in Aβ-treated SH-SY5Y cells.

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Key words

Alzheimer’s disease,Amyloid-Β peptide,Cognitive deficit,Mitochondrial impairment,Orexin-A

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