Polyozellin alleviates atopic dermatitis-like inflammatory and pruritic responses in activated keratinocytes and mast cells.

•Polyozellin inhibits inflammation and pruritus related AD symptoms.•Polyozellin suppresses the expression of inflammatory cytokines in keratinocytes.•Polyozellin relieves pruritic reaction by inhibiting mast cell degranulation.•Polyozellin is a potential therapeutic agent for treating AD.