The LFA-1 antagonist BIRT377 reverses neuropathic pain in prenatal alcohol-exposed female rats via actions on peripheral and central neuroimmune function in discrete pain-relevant tissue regions.

Shahani Noor,Joshua J Sanchez,Melody S Sun,Zinia Pervin, Jacob E Sanchez,Mara A Havard,Lauren T Epler,Monique V Nysus,Jeffrey P Norenberg,Carston R Wagner,Suzy Davies,Wagner Jennifer L,Daniel D Savage,Lauren L Jantzie,Nikolaos Mellios,Erin D Milligan

Brain, Behavior, and Immunity（2020）

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摘要

•Prenatal alcohol exposure (PAE) creates a risk of neuropathic pain in female rats.•Enhanced T cell proinflammatory factors are observed in PAE nerve-injured females.•PAE augments peripheral-glial proinflammatory factors in female allodynic rats.•Blocking peripheral LFA-1 modulates glial-immune actions, reversing allodynia.•Blocking spinal LFA-1 actions is insufficient to reverse allodynia in female rats.

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关键词

Prenatal alcohol exposure,Neuropathic pain,Glia,Neuroimmune,Peripheral immune,T cells,Spinal cord,Satellite glial cells,Th17,IL-17A

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